Characteristics and mechanisms of resorption in lumbar disc

Lumbar disc herniation (LDH) can be spontaneously absorbed without surgical treatment. However, the pathogenesis and physiological indications for predicting protrusion reabsorption are still unclear, which prevents clinicians from preferentially choosing conservative treatment options for LDH patients with reabsorption effects. The purpose of this review was to summarize previous reports on LDH reabsorption and to discuss the clinical and imaging features that favor natural absorption. We highlighted the biological mechanisms involved in the phenomenon of LDH reabsorption, including macrophage infiltration, inflammatory responses, matrix remodeling, and neovascularization. In addition, we summarized and discussed potential clinical treatments for promoting reabsorption. Current evidence suggests that macrophage regulation of inflammatory mediators, matrix metalloproteinases, and specific cytokines in intervertebral disc is essential for the spontaneous reabsorption of LDH.

Frontiers Intervertebral disc degeneration—Current therapeutic

Integrated analysis of single-cell and bulk RNA sequencing data identifies the characteristics of ferroptosis in lumbar disc herniation

Frontiers New Progress in Basic Research of Macrophages in the

Degenerative Disk Disease: Practice Essentials, Anatomy

JCM, Free Full-Text

Herniated Nucleus Pulposus Workup: Approach Considerations

Can we predict LDH lumbar disc herniation resorption in

PDF] The predictive factors for the resorption of a lumbar disc herniation on plain MRI.

Outcomes of conservative treatment for ruptured lumbar disc herniation.

Does Size Matter? An Analysis of the Effect of Lumbar Disc Herniation Size on the Success of Nonoperative Treatment

Isolated Disc Resorption (IDR)