Pathophysiology of Crohn's disease inflammation and recurrence
Chron’s Disease is a chronic inflammatory intestinal disease, first described at the beginning of the last century. The disease is characterized by the alternation of periods of flares and remissions influenced by a complex pathogenesis in which inflammation plays a key role. Crohn’s disease evolution is mediated by a complex alteration of the inflammatory response which is characterized by alterations of the innate immunity of the intestinal mucosa barrier together with a remodeling of the extracellular matrix through the expression of metalloproteins and increased adhesion molecules expression, such as MAcCAM-1. This reshaped microenvironment enhances leucocytes migration in the sites of inflammation, promoting a TH1 response, through the production of cytokines such as IL-12 and TNF-α. IL-12 itself and IL-23 have been targeted for the medical treatment of CD. Giving the limited success of medical therapies, the treatment of the disease is invariably surgical. This review will highlight the role of inflammation in CD and describe the surgical approaches for the prevention of the almost inevitable recurrence.
Frontiers Comparative diet-gut microbiome analysis in Crohn's disease and Hidradenitis suppurativa
Frontiers Diagnostic and Predictive Value of Immune-Related Genes in Crohn's Disease
Biomarkers of Inflammation in Inflammatory Bowel Disease - ScienceDirect
Crohn's Disease Pathology prsentation unfinshed.pptx
Efficacy and safety of stem cell therapy for Crohn's disease: a meta-analysis of randomized controlled trials, Stem Cell Research & Therapy
Metabolites, Free Full-Text
Predicting diagnostic biomarkers associated with immune infiltration in Crohn's disease based on machine learning and bioinformatics, European Journal of Medical Research
PDF) Crohn's Disease-Associated and Cryptoglandular Fistulas: Differences and Similarities
Therapeutic strategies in Crohn's disease in an emergency surgical setting
Frontiers The value of 7 peripheral blood serum ratios in diagnosis and prediction of disease activity of patients within inflammatory bowel disease individuals
Overview and Risk Factors for Crohn's Disease - Irish Pharmacy News
JCM, Free Full-Text
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