Merkel cell carcinoma (MCC) is a relatively rare, polyomavirus associated, primary neuroendocrine carcinoma of the skin which is usually arising from dermal skin layers. However, the origin of MCC in the subcutaneous tissue is debatable. We report a 58-yearold female patient with an oedematous mass on her left groin that was firm in consistency and had no discoloration or other visible abnormality of the overlying skin. On histology and immunohistology the tumour was consistent with the diagnosis of MCC showing a predominant subcutanous growth pattern. Pelvic magnetic resonance tomography revealed a tumour conglomerate reaching from the subcutis of the left groin to the left paraaortal and parailiacal region indicating widespread lymphogenic metastisation. Despite complete medical work-up no other MCC primary could be detected. In conclusion, predominant subcutaneous growth pattern as well as tumour localization in the groin are uncommon features of MCC. MCC showing the aforementioned features may be associated with significant delay of diagnosis and therefore represents an unfavourable prognostic factor.
Merkel cell carcinoma
Diagnostics, Free Full-Text
Interesting case of an abdominal wall Merkel cell carcinoma highlighting the importance of developing an Australian clinical practice guideline
Periocular dermatoses. - Abstract - Europe PMC
Tumores de La Piel, PDF, Carcinoma
Merkel cell carcinoma Tidsskrift for Den norske legeforening
Clinical and dermoscopic features of combined cutaneous squamous cell carcinoma (SCC)/neuroendocrine [Merkel cell] carcinoma (MCC) - ScienceDirect
Merkel Cell Carcinoma with Gastric Metastasis, a Rare Presentation: Case Report and Literature Review
A firm mass in the left groin showing no discoloration or other visible
Squamous Cell Carcinoma and Basal Cell Carcinoma of the Vulva and Squamous Cell Carcinoma of the Vagina
Premalignant and Malignant Tumors of the Vulva
Previous Issues - JADPRO
Abstracts from the 8th Drug Hypersensitivity Meeting (DHM) - 2018 - Clinical and Translational Allergy - Wiley Online Library