Cells, Free Full-Text
We present a multidisciplinary approach for predicting how sperm cells with various morphologies swim in three-dimensions (3D), from milliseconds to much longer time scales at spatial resolutions of less than half a micron. We created the sperm 3D geometry and built a numerical mechanical model using the experimentally acquired dynamic 3D refractive-index profiles of sperm cells swimming in vitro as imaged by high-resolution optical diffraction tomography. By controlling parameters in the model, such as the size and shape of the sperm head and tail, we can then predict how different sperm cells, normal or abnormal, would swim in 3D, in the short or long term. We quantified various 3D structural factor effects on the sperm long-term motility. We found that some abnormal sperm cells swim faster than normal sperm cells, in contrast to the commonly used sperm selection assumption during in vitro fertilization (IVF), according to which sperm cells should mainly be chosen based on their progressive motion. We thus establish a new tool for sperm analysis and male-infertility diagnosis, as well as sperm selection criteria for fertility treatments.
Free-living human cells reconfigure their chromosomes in the evolution back to uni-cellularity
Cells, Free Full-Text
Cells, Free Full-Text, freecell online 100
An integrated in vivo/in vitro framework to enhance cell-free biosynthesis with metabolically rewired yeast extracts
Formulation of YSD, a generic all-purpose serum- free medium for insect
Nutrients, Free Full-Text
An illustration of the full-duplex cell-free massive MIMO system.
Cell-Free Synthetic Biology
Mesenchymal stem cells derived exosomes as nanodrug cargo
Cells, Free Full-Text
Cancers, Free Full-Text
Animal Cell: Structure, Parts, Functions, Labeled Diagram
1,700+ Dendritic Cell Stock Illustrations, Royalty-Free Vector Graphics & Clip Art - iStock
