Alveolar macrophages help CD8+ T cells go (anti-)viral

The human immune system is a highly complex network of cells, signals, and responses that is tightly regulated to ensure that the body can fight off infection without damaging its own tissues. Now, researchers from Japan report a new way in which the immune system protects lung tissue from viral infections.

Alveolar macrophages instruct CD8+ T cell expansion by antigen cross-presentation in lung - ScienceDirect

Frontiers The Roles of Tissue-Resident Memory T Cells in Lung Diseases

Peptide antigen presentation and CD8 + T cell responses in respiratory

Frontiers CD8+ T-cell immune escape by SARS-CoV-2 variants of concern

Modulation of immune response by SARS-CoV-2: a) Virus directly

Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer - ScienceDirect

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity - ScienceDirect

Research outcomes

JCI - Cross-presenting CD103+ dendritic cells are protected from influenza virus infection